Metabolism refers to all the chemical reactions that take place within each cell and are essential for life. It involves many interconnected pathways that can be dDetoxification is the physiological removal of toxic substances from the human body. It is mainly carried out by the liver, and to a lesser extent the small intestine, kidneys and lungs. Substances such as nutrients, food additives, pesticides, medications, air pollutants, alcohol and hormones are transformed from being fat-soluble to water-soluble, allowing them to be more easily excreted from the body. The process occurs in two major phases: Phase I primes toxic molecules for deactivation and Phase II finishes the deactivation and prepares for elimination.Poor detoxification can cause symptoms such as headaches, muscle aches, fatigue, allergies, skin disorders, weight gain, bloating, acid reflux and heartburn, excessive sweating, chronic infections, subfertility, low libido, poor mental function and low stress tolerance.The Detoxification test examines genes which impact Phase I reactions in the liver, including the cytochrome P450 oxidases, Phase II conjugation, including the UDP-glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs) and the Phase III antiporter gene ABCB1, which affects the transport of medicines and other substances into and out of cells. It also include genes that help to neutralise ROS - due to toxic intermediates (generated in Phase 1). The report identifies personalised nutritional support required to optimise detoxification.ivided into anabolism and catabolism. Anabolism uses energy to synthesise sugars, fats, proteins and nucleic acids, whereas catabolism releases energy in the form of ATP (adenosine triphosphate), alongside carbon dioxide, water and ammonia.
Over a billion people, about a quarter of the world's population, is now affected by MetS – characterised by abdominal obesity, insulin resistance, hypertension and hyperlipidemia; which can lead to type 2 diabetes, cardiovascular and neurodegenerative diseases.
This Metabolics report describes how nutrients are absorbed and metabolised, and the genetic, nutrient and environmental factors that support metabolic flexibility or can lead to dysfunction. It provides six interconnected personalised pathways: Appetite Regulation, Nutrient Sensing, Sugar Metabolism, Fat Metabolism, Cholesterol and Bile, Mitochondria and Inflammation.
 
All of the Lifecode Gx reports include
personalised, colour coded genotype results
gene function and SNP impact descriptions
clinically relevant SNPs
nutrient and other epigenetic impacts
links to research evidence
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